What chemical materials are used in the antigen reagent test kit?

What chemical materials are used in the antigen reagent test kit ?

Composition of Antigen Reagent Kit

Detection Reagent
Extraction tube (lysing tube)
Extraction swab (swab)
Test card (box)

It should be noted that the extraction tubes of different brands of kits are slightly different. Some brands of extraction tubes are directly packaged with detection reagents, while some brands of extraction tubes and detection reagents are packaged separately and mixed before use.

Sampling swab:

Antigen swabs look similar to cotton swabs used in everyday life, but they are very different. The biggest difference between the two is that the raw material of cotton swabs in daily life is absorbent cotton, while the sampling swabs look similar to ordinary cotton swabs, but the top is actually a flocking swab.

The reason for using a flocked swab is that it is more suitable for sampling and testing. The flocking swab is made of nylon fiber flocking technology, and the front end is coated with short nylon fibers fixed in a vertical manner, so that there is no absorption hole in the collection area of the entire collection swab. In this way, the collected sample will not be dispersed and retained in the fiber, which is conducive to faster and more efficient elution. Relevant data show that flocking swabs can elute more than 85% of the sample collection volume; traditional cotton swabs, especially those made of absorbent cotton, cannot completely collect and elute samples.

In addition, the handle of the antigen swab is mostly made of thermoplastic.

Extraction tube (lysis tube):

As a household extraction tube, it is impossible to achieve a sterile environment. The most important thing is to prevent sampling pollution (such as haze air, dust at home). The pipe body is generally injection molded with Polyethylene (PE), because PE has excellent biological safety, chemical resistance, and more importantly, high barrier performance and high cost performance.

The reason for using a flocked swab is that it is more suitable for sampling and testing. The flocking swab is made of nylon fiber flocking technology, and the front end is coated with short nylon fibers fixed in a vertical manner, so that there is no absorption hole in the collection area of the entire collection swab. In this way, the collected sample will not be dispersed and retained in the fiber, which is conducive to faster and more efficient elution. Relevant data show that flocking swabs can elute more than 85% of the sample collection volume; traditional cotton swabs, especially those made of absorbent cotton, cannot completely collect and elute samples.

In addition, the handle of the antigen swab is mostly made of thermoplastic.

PE is the general-purpose plastic with the largest output. It has the advantages of good processing performance, low cost, non-toxic and tasteless, and good biocompatibility. Ordinary PE can usually be used for medicine bottles, needle caps, syringe push rods, flow regulators for infusion sets, packaging bags for infusion sets and syringes, etc.

Test card (box):

The test card (box) needs to take into account three major properties, good impact resistance, sufficiently high molding fluidity and excellent laser engraving performance, so as to reduce the possibility of damage under different environments such as high and low temperature, and provide higher injection molding processing efficiency. Packaging logos that take into account flexibility and clarity.

The special plastic granules for testing jamming are generally high-impact Polystyrene (HIPS) or polyvinyl chloride (PVC). Good impact resistance can reduce the possibility of damage in different environments such as high and low temperatures, and sufficient molding fluidity can provide Higher injection molding processing efficiency and excellent laser engraving performance can produce packaging marks with both flexibility and clarity.

High-impact polystyrene (HIPS), commonly known as "reformed benzene", belongs to the new national strategic industry new material. Due to the addition of polybutadiene rubber components, this product not only has good impact resistance, but also reduces the light transmittance, hardness and softening temperature of polystyrene products.

NC film:

NC membrane is a thin film with microporous structure, which is made of high molecular polymer cellulose nitrate as raw material and prepared by phase inversion technology. Due to its excellent protein binding ability, it can be applied to a variety of chromogenic methods, and plays an important role in rapid detection technology, and is one of the core raw materials. At present, NC membrane is mainly used in the production of antigen diagnostic reagents and is a key raw material.

The cost ratio of each link of the antigen kit

According to statistics, the cost split of a complete new crown detection kit: auxiliary materials and packaging materials accounted for 50%, detection antigen and antibody accounted for about 16%, nitrocellulose membrane (NC membrane) basically 10%, PVC rubber sheet about At around 2%, the rest is other costs.

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